Daniel Sanghoon Shin Selected Research

Hereditary Folate Malabsorption

10/2012	Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption.
9/2012	Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
5/2012	A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding.
7/2011	Random mutagenesis of the proton-coupled folate transporter (SLC46A1), clustering of mutations, and the bases for associated losses of function.
5/2011	Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption.
12/2010	Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.

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Daniel Sanghoon Shin Research Topics

Disease

14	Neoplasms (Cancer) 01/2022 - 05/2012
6	Hereditary Folate Malabsorption 10/2012 - 12/2010
5	Melanoma (Melanoma, Malignant) 01/2021 - 04/2015
2	Breast Neoplasms (Breast Cancer) 05/2016 - 06/2014
1	Acute Kidney Injury (Acute Renal Failure) 10/2021
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2020
1	Genomic Instability 12/2020
1	Mouth Neoplasms (Oral Cancer) 01/2020
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 01/2018
1	Endometrial Neoplasms (Endometrial Cancer) 06/2016
1	Extramammary Paget Disease (Paget Disease, Extramammary) 05/2016
1	Disease Progression 05/2016
1	Thrombocytopenia (Thrombopenia) 12/2015
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 12/2015
1	Kidney Neoplasms (Kidney Cancer) 04/2015
1	Liver Diseases (Liver Disease) 06/2014
1	Jaundice (Icterus) 06/2014
1	Liver Failure 06/2014
1	Massive Hepatic Necrosis 06/2014
1	Ascites 06/2014

Drug/Important Bio-Agent (IBA)

6	Proton-Coupled Folate TransporterIBA 10/2012 - 12/2010
5	Folic Acid (Vitamin M)FDA LinkGeneric 10/2012 - 12/2010
4	Immune Checkpoint InhibitorsIBA 01/2022 - 10/2020
4	InterferonsIBA 01/2021 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2020
2	AntibodiesIBA 01/2022 - 04/2015
2	NivolumabIBA 10/2020 - 04/2015
2	IpilimumabIBA 10/2020 - 04/2015
2	Trastuzumab (Herceptin)FDA Link 05/2016 - 06/2014
2	pembrolizumabIBA 03/2016 - 04/2015
1	Tyrosine Kinase InhibitorsIBA 04/2021
1	ErbB Receptors (EGF Receptor)IBA 04/2021
1	osimertinibIBA 04/2021
1	Small Interfering RNA (siRNA)IBA 12/2020
1	MicroRNAs (MicroRNA)IBA 12/2020
1	CurcuminIBA 01/2020
1	AntioxidantsIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	PolyphenolsIBA 01/2020
1	Interleukin-8 (Interleukin 8)IBA 01/2020
1	CytokinesIBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	SteroidsIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	CateninsIBA 01/2018
1	Interferon gamma ReceptorIBA 01/2017
1	Interferon-gamma (Interferon, gamma)IBA 01/2017
1	LigandsIBA 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 06/2016
1	human ERBB2 proteinIBA 05/2016
1	Ado-Trastuzumab EmtansineIBA 05/2016
1	Programmed Cell Death 1 ReceptorIBA 03/2016
1	romiplostim FDA Link 12/2015
1	erucic acidIBA 12/2015
1	Docetaxel (Taxotere)FDA Link 06/2014
1	Carboplatin (JM8)FDA LinkGeneric 06/2014
1	Epidermal Growth Factor (EGF)IBA 06/2014
1	pertuzumabIBA 06/2014
1	G 338IBA 10/2012
1	Folic Acid AntagonistsIBA 05/2012
1	Pemetrexed (MTA)FDA Link 05/2012
1	Aspartic Acid (Aspartate)FDA Link 12/2010

Therapy/Procedure

8	Therapeutics 01/2021 - 04/2015
2	Immunotherapy 01/2020 - 01/2019
1	Neoadjuvant Therapy 04/2021
1	Oral Administration 01/2020
1	Drug Therapy (Chemotherapy) 06/2014
1	Ambulatory Care (Outpatient Care) 06/2014